2. Signaling Pathways
  3. Anti-infection
    Metabolic Enzyme/Protease
  4. HIV Protease

HIV Protease

HIV Protease

Related Products

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HIV protease, a homodimeric aspartyl protease, is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious virus. HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. HIV protease is a critical drug target in designing anti-retroviral drugs to treat HIV/AIDS (acquired immune deficiency syndrome).

HIV-1 protease permits viral maturation by processing the Gag and Gag-Pro-Pol polyproteins. It recognizes and cleaves more than 12 different substrates leading to viral maturation. Similar to that of HIV-1, HIV-2 protease is also a homodimeric aspartyl enzyme that plays a vital role in the HIV life-cycle through processing of Gag and Gag-Pro-Pol precursor polyproteins leading to viral maturation.

HIV Protease Related Products (147):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N3502
    20(21)-Dehydrolucidenic acid A
    		Inhibitor
    20(21)-Dehydrolucidenic acid A is a triterpenoid isolated from the fruiting body of the fungus Ganoderma sinense. 20(21)-Dehydrolucidenic acid A has weak anti-HIV-1 protease activity.
    20(21)-Dehydrolucidenic acid A
  • HY-N0554R
    Escin IA (Standard)
    		Inhibitor
    Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression.
    Escin IA (Standard)
  • HY-P2138
    U-85548E
    		Inhibitor
    U-85548E is an HIV protease inhibitor with nanomolar affinity for HIV-1 aspartic protease. By studying its structure-activity relationship, a potent nanomolar inhibitor with inhibitory effects on both HIV-1 and HIV-2 proteases was designed, and its binding mode was studied by X-ray crystallography and molecular modeling.
    U-85548E
  • HY-14588R
    Lopinavir (Standard)
    		Inhibitor
    Lopinavir (Standard) is the analytical standard of Lopinavir. This product is intended for research and analytical applications. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of the HIV-1 protease, with Kis of 1.3 to 3.6 pM for wild-type and mutant HIV protease. Lopinavir acts by arresting maturation of HIV-1 thereby blocking its infectivity. Lopinavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 14.2 μM.
    Lopinavir (Standard)
  • HY-P2344
    HIV Protease Substrate 1
    HIV Protease Substrate 1, a fiuorogenic HIV protease substrate, can be used to study enzymatic activity of HIV protease.
    HIV Protease Substrate 1
  • HY-161270
    HIV-1 protease-IN-13
    		Inhibitor
    HIV-1 protease-IN-13 (compound 18d) is a potent HIV-1 protease inhibitor with an IC50 value of 0.54 nM. HIV-1 protease-IN-13 also shows potent activity against HIV-1DRVRS (DRV-resistant mutation) and HIV-1NL4_3 variant (wild type).
    HIV-1 protease-IN-13
  • HY-123608
    JE-2178
    		Inhibitor
    JE-2178 is an orally available HIV-1 protease inhibitor with IC50 and Ki values are 15 and 0.318 nM respectively. JE-2178 has antiviral activity.
    JE-2178
  • HY-P3934
    HIV Protease Substrate I
    HIV Protease Substrate I is a chromogenic substrate of HIV-1 protease. HIV Protease Substrate I has the cleavage site of HIV protease.
    HIV Protease Substrate I
  • HY-151250
    HIV-1 protease-IN-7
    		Inhibitor
    HIV-1 protease-IN-7 (compound 16) is an orally active HIV-1 protease inhibitor (IC50=3.52 nM, EC50=37 nM).
    HIV-1 protease-IN-7
  • HY-106920
    Kynostatin 272
    		Inhibitor
    Kynostatin 272 (KNI 272) is a potent HIV protease inhibitor. Kynostatin 272 inhibits the activity of the HIV protease by simulating the substrate transition state of the HIV protease, thus preventing a key step in the replication of the HIV virus. Kynostatin 272 provides an important research foundation for the development of drugs for HIV and AIDS.
    Kynostatin 272
  • HY-121111
    Agaritine
    		Inhibitor
    Agaritine is a compound isolated from the commonly cultivated commercial mushroom Agaricus bisporus. Agaritine is hydrolyzed by an enzyme system present in the mushroom into 4-(hydroxymethyl)benzenediazonium ion, which is a carcinogen in mice. Agaritine is structurally similar to some known carcinogens and can be used for research in cancer and food safety.
    Agaritine
  • HY-159669
    Stercobilin hydrochloride (mixture of isomers)
    		Inhibitor
    Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a Ki of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections.
    Stercobilin hydrochloride (mixture of isomers)
  • HY-150549
    HIV-1 protease-IN-6
    		Inhibitor
    HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor, with an IC50 of 21 pM and a Ki of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir)-resistant variant, even more than wild type virus.
    HIV-1 protease-IN-6
  • HY-P2344A
    HIV Protease Substrate 1 TFA
    HIV Protease Substrate 1 TFA, a fiuorogenic HIV protease substrate, can be used to study enzymatic activity of HIV protease.
    HIV Protease Substrate 1 TFA
  • HY-162525
    GS-9770
    		Inhibitor
    GS-9770 is an orally active inhibitor for HIV protease with Ki of 0.16 nM. GS-9770 exhibits antiviral activity aginst HIV-1 strains and HIV-2 strains with EC50 of 1.9-26 nM, and 26 nM. GS-9770 is metabolic stable in human liver microsomes. GS-9770 exhibits good pharmacokinetic characters in Sprague Dawley rats.
    GS-9770
  • HY-106188
    L 756423
    		Inhibitor
    L 756423 is a potent HIV protease inhibitor. L 756423 has the potential for the research of HIV infection.
    L 756423
  • HY-19232
    R-87366
    		Inhibitor
    R-87366 is a water-soluble human immunodeficiency virus (HIV) protease inhibitor. R-87366 has potent inhibitory for HIV protease with a Ki value of 11 nM. R-87366 can be used for the research of anti-human immunodeficiency virus (HIV).
    R-87366
  • HY-120331
    U-89360E
    		Inhibitor
    U-89360E is an inhibitor for HIV-1 protease. U-89360E inhibits the protease of HIV-1 wildtype, V82D mutant and V82N mutant with Ki of 20 nM, 560 nM and 2100 nM, respectively.
    U-89360E
  • HY-120390
    L 694746
    		Inhibitor
    L 694746 is the metabolite of L-689502 (HY-U00261). L 694746 is an inhibitor for HIV-1 protease with an IC50 of 1 nM and a Ki of 0.34 nM.
    L 694746
  • HY-90001S1
    Ritonavir-13C,d3
    		Inhibitor
    Ritonavir-13C,d3 is the 13C- and deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM.
    Ritonavir-<sup>13</sup>C,d<sub>3</sub>